Small ubiquitin-related modifier sumo

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WebJul 22, 2014 · Small ubiquitin-related modifier (SUMO) is a posttranslational modification essential for many functions in eukaryotic cells. A better understanding of the role of this … WebSmall ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma. Data show that substantial increases in the binding of small ubiquitin-like modifier 2 (SUMO-2) to active DNA regulatory elements in response to heat stress.

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WebConsequently, a large amount of M. mulatta TNF-α (mmTNFα) is required to further understand TNF-α-related pathogenesis and evaluate novel human TNF-α (hTNFα) … WebThe small ubiquitin-like modifier (SUMO) modification alters the subcellular distribution and function of its substrates. Here we show the major role of SUMO during the development of the Caenorhabditis elegans reproductive system. smo-1 deletion mutants develop into sterile adults with abnormal somatic gonad, germ line, and vulva. daniel footwear nhs discount

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WebNov 6, 2024 · This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of … WebThe small ubiquitin-like modifier (SUMO) is a member of the ubiquitin-like superfamily, which consists of three family members in vertebrates (SUMO1-3) (for review, see Melchoir 2000; Alarcon-Vargas and Ronai 2002; Müller et al. 2004) and a single member (SMT3) in invertebrates (Schwarz et al. 1998).SUMO conjugation has been shown to affect … WebA key mechanism is the posttranslational modification of Tfs via conjugation with small ubiquitin-related modifier (SUMO) proteins. SUMO modification primarily affects proteins of the transcriptional machinery, with effects on DNA binding activity, subcellular localization of Tfs, interaction of Tfs with coregulators, and chromatin structure [64]. birth certificate in ghana

Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and …

WebSep 23, 2004 · Covalent attachment of small proteins to substrates can regulate protein activity in eukaryotes. SUMO, the small ubiquitin-related modifier, can be covalently linked to a broad spectrum of substrates. An understanding of SUMO’s role in plant biology is still in its infancy. In this review, we briefly summarize the enzymology of SUMO conjugation … WebFeb 22, 2005 · Importantly, Sp100 and PML are both covalently linked to small ubiquitin-related modifiers (SUMOs). Therefore, we investigated whether SUMO proteins are independent autoantigens in PBC and studied 99 PBC sera samples for reactivity against NDs, PML, and Sp100, as well as against SUMO-2 and SUMO-1 recombinant proteins. birth certificate in goaWebSUMOylation by generating mature small ubiquitin-related modifiers (SUMO) for protein conjugation (endopeptidase activity)andremovingconjugatedSUMOfromtargets(isopep … daniel footwear muswell hill

"WebSep 7, 2007 · Small ubiquitin-related modifier (SUMO) 3 belongs to a family of ubiquitin-like proteins that, similar to ubiquitin, are conjugated to their substrates by a dedicated ligation system. Conjugation of SUMO in most cases results in altered subcellular localization of the modified protein, with consequent effects on its activity. " - Small ubiquitin-related modifier sumo

Small ubiquitin-related modifier sumo

WebCovalent attachment of the small ubiquitin-like modifier (SUMO) to key targets in the proteome critically regulates the evolutionarily conserved … WebAug 10, 2008 · For human male meiosis, we previously showed that the small ubiquitin-related modifier-1 (SUMO-1) protein localizes to chromatin axes in early pachytene spermatocytes, then to kinetochores as meiosis progresses. Here, we delineate possible functional roles based on subcellular localization for SUMO-1 and SUMO-2/3.

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WebJun 9, 2004 · Small ubiquitin-related modifier (SUMO) family proteins function by becoming covalently attached to other proteins as post-translational modifications. SUMO modifies many proteins that participate in diverse cellular processes, including transcriptional regulation, nuclear transport, maintenance of genome integrity, and signal transduction. WebThe small ubiquitin-like modifier (SUMO) modification alters the subcellular distribution and function of its substrates. Here we show the major role of SUMO during the development …

WebMar 15, 2012 · SUMO (small ubiquitin-related modifier) conjugation is a reversible three-step process of protein post-translational modifications mediating protein-protein … WebThis gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a …

WebReprints Abstract Abstract Small ubiquitin-related modifier (SUMO) family proteins function by becoming covalently attached to other proteins as post-translational modifications. WebSep 27, 2004 · Small ubiquitin-related modifier 1 Short names SUMO-1 Alternative names GAP-modifying protein 1 ( GMP1) SMT3 homolog 3 Sentrin Ubiquitin-homology domain …

WebApr 8, 2024 · The small cellulose-binding domain ( sCBD) derived from Trichoderma reesei (AEP40512.1), SUMO domain (amino acids 21-97) of bdSUMO (XP_003564931.1), bdSENP1 (catalytic region; amino acid positions 242-481, XP_003567671.1), green fluorescent protein ( GFP ), hIL6 (mature region from amino acid positions 30-212, P05231), hLIF (active …

WebMar 15, 2012 · SUMO (small ubiquitin-related modifier) conjugation is a reversible three-step process of protein post-translational modifications mediating protein-protein interactions, subcellular compartmentalization and regulation of transcriptional events. Among divergent transcription factors regulated by SUMOylation and deSUMOylation, the … birth certificate in idahoWebThe small ubiquitin-like modifier (SUMO) is a member of the ubiquitin-like superfamily, which consists of three family members in vertebrates (SUMO1-3) (for review, see … birth certificate in germanyWebMay 2, 2024 · Small ubiquitin-related modifier (SUMO)–specific protease 2 (SENP2) is responsible for de-SUMOylation of target protein, with broad effects on cell growth, signal … birth certificate in greensboro ncWebAntigen: Small ubiquitin-related modifier (SUMO) Available to For-Profits: Yes Antigen Species: C. elegans Hybridoma Cells Available (Non-Profit): Yes Isotype: MIgG1, kappa light chain Depositor: Pelisch, F. / Hay, R.T. Host Species: mouse Antigen Sequence: Positive Tested Species Reactivity: C. elegans Depositors Institution: University of Dundee daniel fox facebookWebThe Small Ubiquitin-related Modifier, SUMO-1, [1] [2] is a ubiquitin-like family member that is conjugated to its substrates through three discrete enzymatic steps (see the figure on the right): activation, involving the E1 enzyme ( SAE1 / SAE2 ); [3] conjugation, involving the E2 enzyme ( UBE2I ); [4] [5] substrate modification, through the … birth certificate in indianaWebOct 11, 2010 · Surprisingly, these studies implicate CCNB1IP1 as a SUMO (Small Ubiquitin-like Modifier) E3 ligase. SUMOylation modulates many behaviors of proteins, including interactions with other proteins, subcellular localization, and stabilization though competition with Ubiquitin for lysine residues . birth certificate in ilWebThis technique is a non-binding method that separates protein samples with different molecular sizes under mild conditions. Size exclusion chromatography (SEC) can be used for protein purification, in which it usually dilutes the sample, or for group separation, which is mainly used for desalting and buffer exchange of samples. birth certificate in haryana