Slc protein family

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August undefined, 2024

Web17 rows · This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of ... WebTwo families (SLC3 and SLC7) only generate functional transporters as heteromeric partners, where one partner is a single TM domain protein. Membrane topology predictions for other families suggest 3, 4 6, 7, 8, 9, 10, 11, 12, 13, or 14 TM domains.

SLC transporters as therapeutic targets: emerging …

WebJul 28, 2024 · The solute carrier (SLC) protein superfamily accounts for over 50% of all transport-related proteins and about 10% of all membrane proteins encoded by the human genome. With more than 400 annotated members, it is the largest superfamily of membrane transporter proteins [ 1, 2 ]. WebAmong the SLC family proteins, OAT1 (SLC22A6), OCT2 (SLC22A2), and OAT3 (SLC22A8) are the most important transporters in kidney tissue. Because the activity of these pumps is often the limiting factor for solute clearance from the kidney, ... Thus, these new SLC protein-expressing cell models are robust tools for toxicological testing. japanese names for boys in english

Analysis and update of the human solute carrier (SLC) gene superfamily …

WebLooking for Your Favorite fairlife Brand? Use our Product Locator to find out where to buy fairlife ® ultra-filtered milk products and Core Power ® protein shakes online and at a … WebJan 17, 2024 · The solute carrier (SLC) protein families mediating amino acid uptake in human cells are SLC1, SLC3, SLC6, SLC7, SLC16, SLC17, SLC25, SLC32, SLC36, SLC38, and SLC43 (1). While SLC25 is a family of mitochondrial transporters and SLC17 and SLC32 mediate vesicular amino acid transport, the transporters of the other families are … WebJan 24, 2024 · Expressions of SLC family proteins are differential in various types of digestive system neoplasms, and different SLC family proteins may play an opposite role in the same type of digestive system neoplasms. japanese names for boys meaning dark

Solute Carrier Protein - an overview ScienceDirect Topics

Solute carrier transporters: potential targets for digestive system ...

WebSolute carrier (SLC) transporter family has dual roles in BBB transport with members functioning in the capacity of influx or efflux. They transport a wide variety of solutes, including glucose and amino acids ( Bai et al., 2024 ). WebCAT1 (SLC7A1) is a ~ 67 kDa ubiquitously expressed glycosylated transmembrane protein encoded by SLC7A1 which belongs to cationic amino acid transporters (CAT) subfamily within the solute carrier (SLC) 7 family. In non-hepatic tissues, this high-affinity, low capacity permease mediates the bidirectional transport of cationic amino acids ... lowe\u0027s in lee\u0027s summitWebNov 21, 2013 · The cation chloride cotransporter (CCC) protein family belongs to the solute carrier (SLC) gene series that encodes passive transporters, ion transporters, and exchangers. ... It could either belong to the CCC family or might even represent a new SLC protein family. Further phylogenetic analyses of all SLC series and structural analyses are ... japanese names for boys list

"WebDec 18, 2024 · SLC family, which includes more than 450 genes, is the sec- ... endogenous SLC protein. We selected SLC38A2 for endoge-nous tagging at the N terminus (Figure 3 A). SLC38A2 protein. " - Slc protein family

Slc protein family

WebApr 30, 2024 · SLC16A family members play crucial roles in tumorigenesis and tumor progression. However, the exact role of distinct members in the SLC16A family in human … WebSolute carrier (SLC) transporters — a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological membranes — …

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WebThe solute carrier (SLC) protein family consists of 55 gene families with at least 362 protein-coding genes that mediate transport of a wide spectrum of molecules across … WebMar 30, 2024 · The tetraspanin protein family members are ubiquitously expressed in higher organisms and involved in a wide range of ... Hybrid B6D2F1 male and female mice were purchased from Japan SLC. All ...

WebSep 12, 2024 · The SLC transporter superfamily comprises more than 400 membrane-bound proteins that facilitate the transport of a wide range of substrates – including endogenous molecules, nutrients, and xenobiotics (among them drugs) – across biological membranes. WebJun 26, 2015 · Solute carrier (SLC) transporters — a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological …

The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families. Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee (HGNC) and is the … See more By convention of the nomenclature system, members within an individual SLC family have greater than 20-25% sequence identity to each other. In contrast, the homology between SLC families is very low to non-existent. … See more The following families are named under SLC: 1. high-affinity glutamate and neutral amino acid transporter 2. facilitative GLUT transporter See more • Outline of families • Datasets and Reagents on the Solute Carrier Family • List of proteins at HGNC website See more Most members of the SLC group are located in the cell membrane, but some members are located in mitochondria (the most notable one being SLC family 25) or other intracellular organelles. See more Names of individual SLC members have the following format: where: • SLC is the root name (SoLute Carrier) • n = an integer … See more Putative SLCs, also called atypical SLCs, are novel, plausible secondary active or facilitative transporter proteins that share ancestral … See more WebAbstract Members of the superfamily of solute carrier (SLC) transmembrane proteins transport diverse substrates across distinct cellular membranes. Three SLC protein families transport distinct neurotransmitters into synaptic vesicles to enable synaptic transmission in the nervous system.

WebApr 23, 2024 · With more than 400 members, the solute carrier (SLC) membrane transport proteins are the largest family of transporters, yet, they are pharmacologically underexploited relative to other protein families and many of the available chemical tools possess suboptimal selectivity and efficacy. lowe\u0027s in lake in the hillsWebEach compact dish is filled with macronutrients, balanced calories and protein. Select meals made from a wide range of organically-sourced meats, fish, grains, oats, veggies and … japanese names for boys meaningWebMay 31, 2024 · Abstract. The solute carrier (SLC) superfamily is one of the major sub-groups of membrane proteins in mammalian cells. The solute carrier proteins include more than … japanese names for boys that mean deathWebSolute carrier family. The solute carrier ( SLC) group of membrane transport proteins include over 400 members organized into 66 families. [1] [2] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee ( HGNC) and is the basis for the ... japanese names for boys that mean ghostWebNormal Function. The SLC25A24 gene provides instructions for producing a protein that is a member of the solute carrier (SLC) family of proteins. Proteins in the SLC family transport … japanese names for boys starting with sWebMembers of the Organo Anion Transporter (OAT) Family ( organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs are present in the lipid bilayer of the cell membrane, acting as the cell's gatekeepers. japanese names for boys that mean braveWebMyChart. Manage your health on the go easily with the NEW SCL Health App. Schedule a video visit, message your care team, get secure access to your health information on your … japanese names for boys that mean snow