WebDec 17, 2024 · Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase Antimicrobial Agents and Chemotherapy ASM Journals Antimicrobial Agents and Chemotherapy Vol. 48, No. 5 WebMar 9, 2024 · Topoisomerase IV tracks behind the replication fork and the SeqA complex during DNA replication in Escherichia coli. a detailed characterization of a known potent …
Exploitation of Pare Topoisomerase IV as Drug Target …
WebAug 20, 2024 · In this review, we focused on the importance of unexploited enzyme, ParE, a topoisomerase responsible for the bacterial survival. The bacterial topoisomerases maintain the topological state of DNA. Webtopoisomerase IV (ParC, ParE) (8, 9). The purpose of this study was to investigate the association of quinolone resistance with mutations in the genes coding for gyrase and topoisom-erase IV of S. enterica serovar Typhi and serovar Paratyphi A, which are especially clinically important serotypes of Salmo-nella spp. baseball images png
Topoisomerase - Wikipedia
WebJan 5, 2004 · Topoisomerase IV and DNA gyrase are related bacterial type II topoisomerases that utilize the free energy from ATP hydrolysis to catalyze topological changes in the bacterial genome. WebApr 27, 2024 · Type IIA topoisomerases catalyze a variety of different reactions: eukaryotic topoisomerase II relaxes DNA in an ATP-dependent reaction, whereas the b. Skip to Main Content. ... While Topo II is a dimeric enzyme, the active form of gyrase and Topo IV is a hetero-tetramer, formed by two GyrB/ParE and two GyrA/ParC subunits, respectively (1, … WebAug 21, 2013 · INTRODUCTION. Type II DNA topoisomerases catalyse the transport of one DNA double helix through another in an ATP-dependent reaction ().This manoeuvre allows the control of chromosomal DNA supercoiling and the removal of DNA supercoils, knots and catenanes generated in a variety of biological processes including DNA … baseball il rules