WebBiological Activity for Echinomycin. Echinomycin is a highly potent and selective HIF-1 α inhibitor (IC 50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κ B. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells.. Eradicates mouse … WebEchinomycin has recently been described to inhibit HIF-1 DNA binding and transcriptional activity. In this work, it is shown that echinomycin strongly inhibits the activity of HIF-1 …

Echinomycin Supplier CAS 512-64-1 Focus Biomolecules

WebNov 14, 2024 · To determine the impact of HIF-1 inhibition, we treated 32D Jak2WT or Jak2V617F cells with low doses of the HIF-1 inhibitor echinomycin that intercalates with DNA at HRE, inhibiting binding of HIF ... WebOct 1, 2014 · It has previously been reported that both echinomycin and rapamycin affect the HIF-1 via different mechanisms. Rapamycin inhibits the proliferation of hemangioma endothelial cells by reducing HIF-1–dependent expression of vascular endothelial growth factor. 27 On the other hand, echinomycin is as potent inhibitor of HIF-1 DNA binding … liberty union bar and grille phoenixville

Liposomal formulation of HIF-1α inhibitor echinomycin …

National Center for Biotechnology Information WebTìm kiếm § 707 1 authority purpose coverage and effect on state laws , § 707 1 authority purpose coverage and effect on state laws tại 123doc - Thư viện trực tuyến hàng đầu Việt Nam WebPotent inhibitor of hypoxia-inducible factor 1 (HIF-1) DNA binding activity. Induces apoptosis. Displays antibacterial, antifungal and antiviral activities. Product Details. Alternative Name: ... Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway: J.Y. Park, et al.; Pharmacol. Res. liberty union chester springs menu