Cisplatin sensitivity

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WebNov 15, 1987 · Two sublines were derived from a human bladder carcinoma continuous cell line (RT112-P), one by exposure to fractionated X-irradiation (RT112-DXR8) and the other by continuous exposure to cisplatin (RT112-CP). RT112-DXR8 cells were 1.6- to 2-fold more sensitive to cisplatin and 2 analogues, carbopla … WebOct 7, 2002 · Work from many laboratories has implicated DNA as a critical target for cisplatin cytotoxicity, the most revealing evidence being the hypersensitivity to cisplatin of both prokaryotic and eukaryotic cells deficient in DNA repair ( 3–5 ).

Cisplatin Side Effects: Common, Severe, Long Term - Drugs.com

WebMay 1, 2003 · In such an instance, cancer cells may escape the apoptotic consequence of cisplatin exposure but still sustain major genotoxic insults. Considering that apoptosis may be impaired, using... WebSo, we investigated the anti-cancer drug sensitivity in TMEPAI KO cells. Our results indicated that knock-out of TMEPAI significantly decreased IC 50 for doxorubicin and paclitaxel compared with WT parental cells. However, there are no significant changes in IC 50 for cisplatin and bicalutamide in WT and TMEPAI-KO cells . dhcp server check mac-address

Targeted therapy for cisplatin‐resistant lung cancer via …

WebDetermining the factors that influence cellular sensitivity to cisplatin is thus important for understanding the anticancer activity of cisplatin and for developing a more effective platinum-based chemotherapy. The cytotoxicity of cisplatin arises from its ability to react with DNA and form covalent DNA adducts ( 4 ). WebSep 1, 2024 · The study established that cisplatin sensitivity is associated with changes in expression patterns of key players in cholesterol homeostasis. There is a reliance on cholesteryl ester availability... cigar box wall storage

Reversal of resistance to cisplatin in NSCLC by miRNA-195-5p

Cisplatin Sensitizes Cancer Cells to Ionizing Radiation via Inhibition ...

Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … WebNational Center for Biotechnology Information cigar box upcycleWebAug 1, 2024 · Excellent sensitivity of TC tumors to cisplatin treatment has made TC a highly curable disease. Two features of TC tumors contribute to cisplatin sensitivity, … dhcp server configuration for multiple vlans

"WebFeb 7, 2024 · The cytotoxicity of cisplatin was evaluated in six bladder cancer cell lines to compare their responses to cisplatin. The T24 cancer cells exhibited the lowest sensitivity to cisplatin and was therefore selected to explore the mechanisms of drug resistance. " - Cisplatin sensitivity

Cisplatin sensitivity

WebJan 4, 2024 · Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of such resistance remain elusive. The RNA binding protein with multiple splicing (RBPMS) binds to nascent RNA transcripts and regulates splicing, transport, localization, and stability. WebDec 7, 2024 · TTK silencing increased cisplatin sensitivity by activating the mammalian target of rapamycin (mTOR) complex to further suppress cisplatin-induced …

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WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with ovarian cancer, a staggering 70% will become resistant to the front-line therapy, cisplatin. Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of … WebOct 13, 2024 · Extensive research has been conducted to understand and overcome platinum resistance, and mechanisms of resistance can be categorized into several broad biological processes, including (1)...

WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting with purine bases, activating several signal transduction pathways, and silencing or activating several genes which finally leads to apoptosis. WebJul 14, 2024 · Mechanismly, propofol enhances cisplatin sensitivity of NSCLC through miR-486-5p/RAP1-NF-κB axis. The finding provides a deeper understanding about the molecular mechanism of propofol in the platinum resistance of NSCLC, and might support the application of propofol in NSCLC chemotherapy. Materials and methods Cells culture

WebAug 24, 2024 · Cisplatin (CDDP) remains one of the most widely used first-line drugs in the therapy of NSCLC, based on the clinical data that the poor outcomes of untreated … WebSensitivity to cisplatin in the different groups was measured as the IC 50 concentration after transfection. Growth inhibition rate of the A549 cells was 52.0% under the effect of cisplatin at an IC 50 concentration of 0.8 μg/mL but decreased to 37.6% after transfection with miR-195-5p-ASO.

WebFactors contributing to the observed cisplatin sensitivity include defective DNA damage repair and a hypersensitive apoptotic response to DNA damage. Nonetheless, around 10 …

WebApr 9, 2024 · This unique side effect has been linked to a drug called oxaliplatin, which is used to treat several types of cancer, including … cigar brand te crosswordWebMar 15, 2024 · The results indicated that URI knockdown increased the sensitivity of cells to cisplatin by inhibiting proliferation and promoting apoptosis. The levels of P-ATM, P-CHK2 and γH2AX were detected by Western blot. Increased levels of P-ATM, P-CHK2, and γH2AX were observed in cisplatin treated cells, indicating that cisplatin induced a DNA … dhcp server configuration windows 2016WebJun 24, 2011 · ICL-based chemotherapy is one of the most widely used forms of cancer treatment, particularly in the treatment of leukaemias. Fanconi anaemia (FA) is a disorder that results in sensitivity to... cigar brand crosswordWebAug 1, 1996 · Purpose: Human glioma cell lines resistant (U373MGCP) and sensitive (U373MG) to cisplatin were used to evaluate the effect of cisplatin as a sensitizer to low dose rate irradiation (LDRI). Methods and materials: A cisplatin resistant glioma cell line U373MGCP was developed by chronic exposure of parental U373MG cells to cisplatin. . … cigar box with inlayWebApr 1, 2024 · Abstract. NKX2-1 was shown to enhance cisplatin sensitivity in KRAS-mutated cells, but it conferred cisplatin resistance in EGFR-mutated lung adenocarcinoma … dhcp server configuration in ubuntu 20.04WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with … dhcp server conflict detectionWebMay 17, 2012 · Cisplatin sensitivity correlated with the expression of 454 unique genes (P<0.01), corresponding to 68 pathways. Twenty-three of … dhcp server co to jest