Cisplatin induced cardiotoxicity
WebSecondary prevention of anthracycline-induced cardiotoxicity has also gathered quite some scientific interest. Beta-blockers, aldosterone antagonists, angiotensin receptor blockers, angiotensin converting enzyme inhibitors, neurohormonal blocking drugs and implantable devices have and may still all be used. WebDec 30, 2015 · El-Awady el-SE, Moustafa YM, Abo-Elmatty DM, Radwan A. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. Eur Eur J …
Cisplatin induced cardiotoxicity
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WebJan 27, 2016 · Main features and mechanisms of cardiotoxicity from nonanthracycline chemotherapy. The cardiotoxic effects produced by antineoplastic agents can be permanent (type I CTX) or reversible (type II), and can be induced at distinct levels and intensities. A distinguishing feature of type I chemotherapy-induced CTX is the induction of … WebAfter right heart catheterization, pathological results of a myocardial biopsy from the ventricular septum indicated no cardiac muscle hypertrophy, cardiac fibrosis, inflammatory cell infiltration, or myocyte disarray. Eventually, she was diagnosed as having pemetrexed-induced cardiomyopathy.
WebJan 30, 2024 · Results: Numerous antioxidants (such as thiol compounds, polyphenols, vitamins, etc.) had been reported for their beneficial effects on cisplatin-induced cardiotoxicity. The effects of various antioxidants, including sulfur-containing amino acids, have also been explored for mitigation of cisplatin neurotoxicity. WebIt may be induced by factors including direct toxicity, ion imbalance, heart infiltration and, in the case of neuroendocrine tumors, the influence of tumor excretions. Keywords: …
WebDec 1, 2024 · Cisplatin is a highly effective antitumor agent. However, its use is limited due to severe adverse effects, particularly nephrotoxicity, which occurs in approximately 30% of patients. There is a need for novel renoprotective compounds. WebLung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in …
WebOct 1, 2010 · The increase in MDA may be due to the formation of oxygen-free radicals during cisplatin-induced cardiotoxicity, which react with membrane lipids, proteins, and nucleic acids and can cause ...
WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al., 2024 t shirts raleigh ncWebCardiotoxicity has been well documented as a side effect of cisplatin (CDDP) treatment. The inflammatory response plays a crucial role in the pathological process of CDDP … phil rodgers figure 8WebSep 15, 2024 · Cisplatin's side effects primarily include nephrotoxicity, gastrointestinal toxicity, neurotoxicity and ototoxicity. Cardiotoxicity is generally not defined as a side effect of cisplatin. However, over the past decade there has been a surge in the amount of clinical cases reporting a vast array of cardio-toxic events occurring during or shortly ... phil rodgers hairdressers prestonWebMar 21, 2024 · Cisplatin (CP) kills tumour cells by inducing senescence or triggering innate apoptotic pathways that cause irreparable DNA damage, and it is the most commonly used first-line drug for cancer treatment. 1 However, its clinical use is often limited by dose-related cardiotoxicity, 2 which includes arrhythmias, 3 angina pectoris, 4 and cardiac … phil rodgers figure 8 chippingWebAug 17, 2024 · Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-α-AP-1 Signal Pathway Front Pharmacol. 2024 Aug 17;12:711238. doi: 10.3389/fphar.2024.711238. eCollection 2024. Authors phil roebuckWebRats treated with rhEPO, simultaneously, before, or after Cisp injection, remarkably decreased DNA damage, highlighting an interesting cytoprotective strategy usingrhEPO against Cisp-induced liver and heart injuries. Cisplatin (Cisp) is one of the most effective chemotherapeutic agents. However, at higher doses, liver and heart injuries may occur. … phil rodocker realtorWebJun 1, 2013 · At present, no data is provided explaining the mechanism of NO in cisplatin-induced cardiotoxicity. It has been found that NO and its metabolites, including … phil rogers goldmark issuu