Cancer-testis ct antigens
WebPrized Writing 2015-2016 224 Abstract Cancer-testis (CT) antigens are valuable immunotherapeutic targets in the treatment of cancer. Th e Melanoma-Antigen-A … WebApr 1, 2010 · Cancer/testis antigens (CT antigens) are thought to be suitable targets for antigen-specific immunotherapy, because of the cancer-specific expression except for the testis among various normal tissues and no-expression of HLA class I in the testis. In the present study, the expressions of CT antigens (MAGE-A3, MAGE-A4, NY-ESO-1 and …
Cancer-testis ct antigens
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WebMar 15, 2024 · Cancer/testis (CT) antigens match these criteria for an ideal target, as CT antigens are tumor antigens that are identified with a normal expression and restricted to testicular, ovarian, fetal, and placental germ cells [4,5], but may also be detected in malignancies [6,7]. CT antigens are normally located in an immune-privileged site due to ... WebJan 1, 2004 · Cancer/testis (CT) antigens are immunogenic in cancer patients, exhibit highly tissue-restricted expression, and are considered promising target molecules for cancer vaccines. To date, 44 CT gene families have been identified and their expression studied in numerous cancer types.
WebMar 29, 2012 · Here, we have explored the possible expression of cancer/testis (CT) antigens by ATLL cells, as CT antigens are widely recognized as ideal targets of cancer immunotherapy against solid tumors. A high percentage (87.7%) of ATLL cases (n = 57) expressed CT antigens at the mRNA level: NY-ESO-1 (61.4%), MAGE-A3 (31.6%), and … WebJan 27, 2016 · These gene products were named cancer/testis (CT) antigens in initial studies due to their immunogenicity 12,13. The existence of these genes reflects the similarities between the processes of ...
WebPIWIL2 is a known cancer–testis antigen (CTA), which normally shows restricted expression in male germ cells in the testis and expression in a diverse range of cancer. An accumulating body of evidence has revealed several mechanisms in cancer cells, which allows PIWIL2 overexpression to inhibit apoptosis and promote proliferation [90]. WebTherapeutic cancer vaccine, for nonviral cancers, targets tumor antigens from various classifications including differentiation antigens, overexpressed antigens, or cancer …
WebAs such, these antigens are designated cancer/testis antigens (CT antigens). Since the early 1980s, about 70 families of CT antigens have been identified with over 140 …
Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a … See more With the development of tumor-associated antigens (TAA), the first clone of a human tumor antigen, melanoma antigen-1 (MAGE-1) was reported in 1990s, which elicited an autologous cytotoxic T-lymphocyte (CTL) … See more Germ cells share some features with cancers. The motile and penetrating features and colonization of primitive germ cells resemble the … See more Immunogenicity In normal tissues, CT antigens are exclusively expressed in testis, making it no access to the immune system. Besides, the existence of blood-testis barrier and the lack of human leukocyte antigen (HLA) class I expression … See more CT antigens can be divided by whether they are encoded on the X chromosome (X-CT antigens genes) or not (non-X-CT antigens genes). It … See more The expression of CT antigens genes are exclusively regulated by epigenetic events both in normal and cancer tissues, while DNA methylation and histone post-translational modification remain the most widely characterized epigenetic factors here. See more how much protein in 4 oz canned tunaWebApr 1, 2010 · CD133 and cancer-testis antigens (CTAs) may be potential predicted markers of adjuvant chemotherapy or immune therapy, and they may be the independent prognostic factor of NSCLC. Nowadays, there is… Expand 4 PDF Expression and prognostic significance of cancer-testis antigens (CTA) in intrahepatic cholagiocarcinoma how much protein in 4 oz beefWebNov 1, 2011 · Cancer/Testis (CT) antigens. The term “Cancer/Testis (CT) antigen (or CTA)” was first used in 1997. 50 CT antigens, also known as cancer germline … how do night guards workWebCancer/testis antigens (CTA) are expressed in a variable proportion of a wide range of human tumors but are silent in most normal tissues except the testis. ... CT antigens … how much protein in 4 oz fishWebMar 15, 2024 · Cancer/testis (CT) antigens match these criteria for an ideal target, as CT antigens are tumor antigens that are identified with a normal expression and restricted … how do nigerians communicateWebFeb 5, 2014 · Cancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in this disease are not fully understood. This study measured the expression levels of four CT antigen genes in Chinese patients with MM … how much protein in 4 oz hamburgerWebCancer/testis antigens (CTAs) are considered ideal targets for cancer treatment due to their high immunogenic, restricted expression in germ cells and malignancies. 7–9 Generally, germ cells do not express human leukocyte antigen (HLA) class I molecules, leading them escape from the attack of T cells. Though somatic tissues, such as thyroid ... how much protein in 4 oz meat